Impact of coal mine dust exposure and cigarette smoking on lung disease in Appalachian coalminers

Respiratory Research

Table 2 Radiologic findings of cohort

	Non-coal miners (n=194)		Coal miners (n=362)		p-value
	Never smokers (n=46)	Ever-smokers (n=148)	Never smokers (n=124)	Ever-smokers (n=238)
ILD patterns^a
Simple CWP, %	0	0	32.3	34.5	.67
Complicated CWP, %	0	0	28.2	19.7	.07
Any ILD, not including RB-ILD, %	0	16.2	14.5	34.9	<.01^a
UIP %	0	0.7	2.4	2.5	.42
Probable UIP %	0	1.4	0.8	5.0	.03
NSIP %	0	0.7	4.8	6.7	.01
RB-ILD (including small opacities) %	0	3.4	25.0	12.3	<.01^a
DIP %	0	2.0	0	8.0	<.01^a
CPFE %	0	2.0	0.8	16.0	<.01^a
Organizing pneumonia %	0	2.7	0.8	0.8	.43
Asbestosis %	0	0	2.4	0.8	.17
Other/unclassifiable %	0	4.1	2.4	1.7	.25
ILA patterns	36.9	43.2	29.8	34.0	.12
CL-GGO %	13.0	15.5	8.9	6.3	.02
SPR %	17.4	17.6	8.1	11.8	.09
Mixed CL-GGO+SPR %	10.9	11.5	17.7	21.0	.07
Non-emphysematous cysts %	10.9	7.4	8.1	8.4	.91
Traction bronchiectasis/bronchiolectasis %	21.7	26.3	13.7	18.5	.06
Any Emphysema	13.0	87.8	29.0	77.7	<.01^a
Centrilobular %	10.9	79.7	16.9	71.0	<.01^a
Paraseptal %	2.2	34.5	3.2	53.4	<.01^a
Panacinar %	0	8.1	0.8	9.7	<.01^a
Bullous %	0	4.1	2.4	21.4	<.01^a
Cicatricial %	-	-	18.6	15.1	.40
Pleural plaque/thickening %	0	5.4	14.5	16.8	<.01^a
Dilated main pulmonary artery (ratio PA/Aorta >0.9), %	15.2	18.9	23.4	24.8	.35

CL centrilobular, CPFE combined pulmonary fibrosis emphysema, CWP Coal-workers’ pneumoconiosis, DIP Desquamative interstitial pneumonia, GGO ground glass opacity, ILD interstitial lung disease; NSIP nonspecific interstitial pneumonia, RB respiratory bronchiolitis, SPR subpleural reticular changes, UIP usual interstitial pneumonia
^aSignificant p-value with adjusted α=<.016 as per Bonferroni correction

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