Fig. 4

Adoptive transfer of Serpinb10-deficient BMDMs suppresses allergic airway inflammation and mucous cell metaplasia in mice. A Schematic overview of the mouse experiments. B Representative images of H&E staining of lung sections from OVA-challenged WT mice (1) and Serpinb10^−/− mice (2) depleted of macrophages, OVA-challenged WT mice (3) and Serpinb10^−/− mice (4) depleted of macrophages and transferred with WT BMDMs, OVA-challenged WT mice (5) and Serpinb10^−/− mice (6) depleted of macrophages and transferred with Serpinb10^−/− BMDMs. Scale bar, 50 μm. C Representative images of PAS staining of mouse lung sections. Scale bar, 50 μm. D Lung inflammatory scores and PAS scores were calculated as described in Methods. n = 6 mice per group. Data are mean ± SD. *P < 0.05, ***P < 0.001, ****P < 0.0001