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Table 1 Baseline characteristics at the time of blood collection of the discovery cohort

From: Serum C-C motif chemokine ligand 17 as a predictive biomarker for the progression of non-idiopathic pulmonary fibrosis interstitial lung disease

 

HC*

BA†

COPD‡

NTM§

Bacterial

pneumonia

IPFll

Non-IPF-ILD**

No. of subjects

30

30

28

15

6

86

57

Age (years)

62 (55–73)

67 (48–76)

77 (73–80)

71 (63–78)

68 (59–69)

75 (70–79)

73 (65–76)

Sex (male)

10 (33%)

8 (27%)

24 (86%)

1 (7%)

3 (50%)

66 (77%)

29 (51%)

Smoking history (yes)

1 (3%)

5 (17%)

27 (96%)

0 (0%)

2 (33%)

62 (72%)

30 (53%)

Corticosteroid (yes)

0 (0%)

5 (17%)

0 (0%)

1 (7%)

0 (%)

12 (14%)

22 (39%)

Immunosuppressive agents (yes)

0 (0%)

0 (0%)

1 (4%)

2 (13%)

2 (33%)

3 (3%)

11 (19%)

Antifibrotic therapy (yes)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

18 (21%)

1 (2%)

Serum biomarker

CCL17‡‡ (pg/mL)

230

(194–289)

335

(181–454)

270

(202–389)

259

(164–357)

209

(134–262)

515

(343–767)

418

(330–642)

Classification of ILD

 INSIP§§

N/A

N/A

N/A

N/A

N/A

N/A

14 (25%)

 CTD-ILDllll

N/A

N/A

N/A

N/A

N/A

N/A

24 (42%)

 Unclassifiable ILD

N/A

N/A

N/A

N/A

N/A

N/A

15 (26%)

 FHP***

N/A

N/A

N/A

N/A

N/A

N/A

1 (2%)

 PPFE†††

N/A

N/A

N/A

N/A

N/A

N/A

3 (5%)

  1. Data are presented as the median (interquartile range) or number of patients (percentage)
  2. *healthy control; †bronchial asthma; ‡chronic obstructive pulmonary disease; §nontuberculous mycobacterial infection; llidiopathic pulmonary fibrosis; **interstitial lung disease; ††not available; ‡‡C-C motif chemokine ligand 17; §§idiopathic nonspecific interstitial pneumonia; llllconnective tissue disease-interstitial lung disease; ***fibrotic hypersensitivity pneumonitis; †††pleuroparenchymal fibroelastosis