The association and impact of radiographic, pathological emphysema and spirometric airway obstruction on patients with resectable lung adenocarcinoma

Table 4 Summaries of studies that assessed prognostic value of CT-defined emphysema in patients with lung cancer

Study	Country	Enrolled patients	Histological types	TNM stage	The percentage of never-smokers	Assessment Method of CT-defined emphysema	Matched histological features	Airway obstruction	PPCs
Ueda et al.7	Japan	100	NSCLC	I	0.0%	Quantitative	No	Yes	No
Gullón et al.8	Spain	353	NSCLC	I-IV	10.8%	Quantitative	No	Yes	No
Bishawi et al.9	USA	153	NSCLC	I	45.1%	Visual	No	No	No
Yasuura et al.10	Japan	1062	NSCLC	I-II	NA^*	Quantitative	No	Yes	No
Colombi et al.11	Italy	75	NSCLC	I-III	19.0%	Quantitative	No	Yes	No
Ishida et al.13	Japan	721	NSCLC	I	NA^*	Visual	No	No	Yes
Zhang et al.12	China	854	NSCLC	I-IV	54.8%	Visual+ Quantitative	No	Yes	No
Current Study	China	902	LUAD	I-III	69.5%	Visual+ Quantitative	Yes	Yes	Yes

Abbreviations: CT = computed tomography; NA = Not available; PPCs = postoperative pulmonary complications. *Only pack-years of smoking but not the smoking status was reported in the studies

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