Fig. 4

Cy5-PEG-FUD uptake is increased in liver compared to mutant control, while both peptides appear to be renally cleared. Mice were treated intratracheally with bleomycin (1 U/kg, IT) or normal saline. At indicated time points, Cy5-PEG-FUD or Cy5-PEG-mFUD (0.1875 mg/kg Cy5-labeled peptide in 12.5 mg/kg mass dose) were administered subcutaneously. One day later, liver (A, B) and kidney (C, D) tissues were collected. (A) Representative images of livers are included. (B) Total radiant efficiency was quantified in livers. (C) Representative images of kidneys are included. (D) Total radiant efficiency was quantified in kidneys. n ≥ 3 mice/group. Data are represented as mean ± SD